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cenobamate will lower the extent or result of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Enhance dose of CYP3A4 substrate, as desired, when coadministered with cenobamate.brimonidine and fentanyl transdermal each raise sedation. Stay clear of or Use Alternate Drug. Restrict